A Review Of indazole carboxamide
Substitution at R3 using a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency with the halide analogs (74g–h) demonstrating highest the potency within the group. Additional optimization triggered the invention of 74i–j, with 74k as one of the most Energetic compound from the sequence (pIC50 = six.77) with excell